Question

What is an example of an amide?

Answer 1

Amide group:

• When the Carboxyl group reacts with the molecule of the Amine group which upon heating form an Amide group.
• They are represented by the general formula $\mathrm{R}-\mathrm{CO}-{\mathrm{NH}}_2$.

Example of an amide:

• Aliphatic and aromatic primary and secondary amines undergo into acylation reaction when treated with acid chlorides, anhydrides, or esters to form a nucleophilic substituted amide.
• This reaction consists of the replacement of the hydrogen atom of $-{\mathrm{NH}}_2\mathrm{or}-\mathrm{NH}$ group.
• To shift the equilibrium to the right-hand side, the $\mathrm{HCl}$ formed during the reaction is removed as soon as it is formed.
• This reaction is carried out in the presence of a base (such as pyridine) which is stronger than the amine.