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Question

How is correct chromosome attachment achieved?


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Solution

Correct chromosome attachment

  1. In meiosis, proper chromosomal attachment is assumed to be acquired through a trial and error process in which only the correct orientation is fixed, allowing passage to anaphase.
  2. The majority of homolog pairs achieve accurate bipolar alignment early in meiosis I, and the kinetochore tension caused by this alignment results in attachment stabilization.
  3. Some homolog pairs can be attached with an incorrect alignment at first, but these incorrect attachments are unable to induce tension at the kinetochore.
  4. As a result, they are not secure in their current location.

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