Mitochondria produces ATP using a chemiosmosis mechanism. When electrons move in the electron transport chain, protons are pumped into intermembrane space of mitochondria. It results in the accumulation of protons in the intermembrane space and results in the development of proton gradient across the membrane. This proton gradient is broken down by the movement of protons to the matrix by the facilitated diffusion through the membrane channel of ATP synthase, i.e. F0 down the electrochemical gradient. This movement provides sufficient energy and couples with the synthesis of ATP by the F1 component of ATP synthase. For the production of each ATP molecule, 2 protons are pumped from the intermembrane space to the matrix.
- Significance of Glycolysis
- TCA cycle or Krebs cycle
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