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Question

If both parents are carriers for thalassemia, which is an autosomal recessive disorder, what are the chances of pregnancy resulting in an affected child?


A

100%

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B

50%

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C

25%

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D

nil

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Solution

The correct option is C

25%


The correct option is C:

Explanation of the correct option:

  1. An autosomal recessive disorder like thalassemia is caused by abnormalities in both members of a pair of genes, or so they generally thought.
  2. Both parents may have a single dose of the gene on one chromosome but a normal gene on the other, preventing the sickness from manifesting in the carrier parent, which is quite significant.
  3. To be truly impacted by the condition, a kid must inherit one faulty gene from each parent.
  4. Parents who are both carriers of a typically autosomal recessive ailment have a 25% chance of having an affected child and a 50% chance of having normal-appearing carriers.

Explanation of the incorrect option:

Option A:

Chances of 100% affected child is impossible because for that both the parents should be diseased.

Option B:

Chances of 50% affected child is impossible because for that one of the parents should be diseased.

Option D:

There is 25% chance of child being affected with thalassemia because both the parents are carrier of the thalassemia.

Final answer: If both parents are carriers for thalassemia, which is an autosomal recessive disorder, then 25% chances of pregnancy resulting in an affected child


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