What Are the Main Steps of Translation?

Translation is the process of polypeptide chain formation from the mRNA template. The main steps of translation are:

  • Amino acid activation – Charging or aminoacylation of tRNA.
  • Initiation – Binding of mRNA and aminoacylated tRNA to the small subunit of ribosome followed by the large subunit.
  • Elongation – Formation of peptide bonds and growth of polypeptide chain until the ribosome reaches the stop codon in mRNA.
  • Termination – After reaching stop codon, translation terminates. mRNA and protein dissociate from the ribosome.

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