Question

What does aneuploidy in cancer lead from?

Answer 1

Aneuploidy in cancer:

1. Chromosomal abnormalities are genetic disorders caused by a change in one or more chromosomes or an incorrect arrangement of the chromosomes.
2. Aneuploidy in cancer is caused by chromosomal instability (CIN).
3. Aneuploidy in cancer is characterized by an increase in the rate of losses or gains of entire chromosomes or substantial sections of them.
4. In contrast to genetic instability caused by an elevated incidence of point mutation, chromosomal instability is likely to be ubiquitous and significant in several human malignancies, despite the fact that various forms of cancer demonstrate varying amounts of instability.
5. Some malignancies, such as the limited number of breast or colon tumors with defective mismatch repair pathways, have relatively stable chromosomes.