What Is Denaturation Of Proteins?

Denaturation is the loss of appropriate tertiary structure caused by disintegrating the non-covalent bonds in a protein. Proteins can be denatured by pH changes, heat, and some chemicals, any of which that disrupts salt bridges, H-bonds, or hydrophobic interactions. Any disulfide bonds must also be broken in order for complete denaturation of proteins. It is not essential to disrupt all the non-covalent forces to disrupt conformation and ruin function.

With some proteins, denaturation is irreversible and the protein is damaged permanently. With other proteins, the process of denaturation can be reversed in case the denaturing agent is removed, which is called renaturation.

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