Myeloblast vs. Lymphoblast

At the time of hematopoiesis, from the hemocytoblast, two types of progenitor cells are differentiated – myeloblast and lymphoblast. The hemocytoblast is a multipotent stem cell that can differentiate into different types of precursor cells.

Myeloblast

• These are immature types of WBC.
• Their cells are formed in the bone marrow, and when such immature cells mature, they become matured white blood cells, referred to as granulocytes.
• These are the precursor cells of eosinophil, neutrophil and basophil.
• These are large cells with some cytoplasm and with slightly irregular or round nuclei having thin chromatin and 3-5 evident nucleoli.
• Myeloblasts are of the following types, depending on the nature of granules:
  • Granular
  • Pauci granular
  • Agranular

Lymphoblast

• It is an immature cell that matures further into the lymphocyte, precursors of lymphocytes.
• These are large cells with some cytoplasm and with slightly irregular or round nuclei having compacted chromatin and nucleoli that are inconspicuous.
• These are progenitor cells of the B and T lymphocytes.
• The differentiation process of lymphoblast into lymphocytes is lymphopoiesis. If there is an overproduction of lymphoblasts in the bone marrow, it leads to a condition of Acute Lymphocytic Leukaemia (ALL).

Key Differences Between Myeloblast and Lymphoblast

The table below depicts the differences between Myeloblast and Lymphoblast.

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