Question

Assertion: Competitive inhibitors compete with the natural substrate for their attachment on the active sites of the enzyme.

Reason: In competitive inhibition, the inhibitor binds to the allosteric site of the enzyme.

Choose the correct option.

• A. Both Assertion and Reason are correct and Reason is the correct explanation for Assertion
• B. Both Assertion and Reason are correct but Reason is not the correct explanation for Assertion
• C. Both Assertion and Reason are incorrect
• D. Assertion is correct but Reason is incorrect
• E. Assertion is incorrect but Reason is correct
• F. Answer required

Answer 1

Answer: (D)

Assertion is correct but Reason is incorrect

Drugs compete with the natural substrate for their attachment on the active sites of enzymes. Such drugs are called competitive inhibitors.

Some drugs do not bind to the enzyme’s active site. These bind to a different site of enzyme which is called allosteric site. This binding of inhibitor at the allosteric site changes the shape of the active site in such a way that the substrate cannot recognise it.

So, in competitive inhibition, it competes with the natural substrate for their attachment on the active sites of enzymes and it doesn't bind to the allosteric site.

Hence, option D is correct.