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Question

At high altitude, the RBC in human blood


A
Increase in size.
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B
Decrease in size.
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C
Increase in number.
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D
Decrease in number.
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Solution

The correct option is D Increase in number.
At high altitudes, there is a decrease in oxygen hemoglobin saturation. This hypoxic condition causes hypoxia-inducible factor 1 (HIF- 1) to become stable and stimulates the production of erythropoietin (EPO), a hormone secreted by the kidneys. EPO stimulates red blood cell production from bone marrow in order to increase hemoglobin saturation and oxygen delivery. Thus, the total number of RBC increases.

Biology

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