Question

Colchicine is a drug known to stop the formation of spindle fibres. what will happen to when dividing cells in a cell culture are treated with colchicines

• A. Cells will die
• B. Cells will not enter into cell cycle
• C. Cells will enter into cell cycle but get arrested in metaphase
• D. Cells will complete the cell cycle

Answer 1

Answer: (C)

Cells will enter into cell cycle but get arrested in metaphase

Since colchicines inhibits growth of spindle fibres and the major role of spindle fibre is to pull the chromosomes to the poles during anaphase. So, colchicines treated cells will enter in cell cycle but will be arrested at metaphase.