Question

During the processing of the prohormone “proinsulin” into the mature “insulin” -

• A. B–peptide is removed from proinsulin
• B. B–peptide is added to proinsulin
• C. C–peptide is added to proinsulin
• D. C–peptide is removed from proinsulin

Answer 1

The correct option is D C–peptide is removed from proinsulin

An extra stretch called as C-peptide is present in the proinsulin. C-peptide is not present in the mature insulin and it is removed during the maturation process in which proinsulin is converted into insulin. This is the major difference between insulin and proinsulin.
So, the correct answer is- C-peptide is removed from proinsulin.