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Question

If the father has autosomal dominant disease, then what will be the probability of having an affected offspring irrespective of sex of the child, if the mother is unaffected?
  1. 90%
  2. 10%
  3. 50%
  4. 100%


Solution

The correct option is C 50%
In an autosomal dominant disorder, the mutated gene is a dominant gene located on one of the nonsex chromosomes (autosomes).
Only one mutated gene is necessary to be affected by this type of disorder. A person with an autosomal dominant disorder — in this case, the father — has a 50% chance of having an affected child with one mutated gene (dominant gene) and a 50% chance of having an unaffected child with two normal genes (recessive genes) irrespective of the sex of the child. 

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