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Question

In rare circumstances, death of the foetus might occur with which of the below combinations of parent and child?


A

Rh+ father and Rh+ mother

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B

Rh- father and Rh- mother

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C

Rh+ father and Rh- mother

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D

Rh- father and Rh+ mother

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Solution

The correct option is C

Rh+ father and Rh- mother


Rh+ children could be born to a Rh- woman and an Rh+ man. In such a case, the first pregnancy usually stays safe, while there could be a risk associated with the subsequent pregnancies. The reason for such sensitivity in the mother is that some of the RBCs from the fetus get into the bloodstream of the mother during the miscarriage or delivery. The mother's immune system responds to the foreign Rhesus antigen causing her to produce anti-Rh antibodies. The mother produces the anti-Rh antibodies in some time. However, if such a mother gets pregnant again with an Rh+ foetus, the foetus would get exposed to the anti Rh+ antibodies already produced by the mother. As a result, serious damage to the red blood cells of the foetus can occur and may lead to the death of the foetus, if left undiagnosed and untreated.


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