is it possible for two siblings having the blood group AB and O one male and another female respectively.

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Solution

Suppose the genotype of father is I^Ai (Blood group) and that of the mother is I^Bi (blood group B).

Gametes: Father- I^A, i Mother- I^B, i

Progeny:

I^A i

I^B I^AI^B
(Blood group AB) I^Bi
(Blood group B)

i I^Ai
(Blood group A) ii
(Blood group O)

So, yes the children of this couple can have either blood group A, B, AB or O.

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	I^A	i
I^B	I^AI^B (Blood group AB)	I^Bi (Blood group B)
i	I^Ai (Blood group A)	ii (Blood group O)