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Question

Ketone bodies are formed due to: 
  1. Hyposecretion of insulin
  2. Hyper secretion of insulin
  3. Hyposecretion of glucagon
  4. All of these


Solution

The correct option is A Hyposecretion of insulin
Prolonged hyperglycemia leads to a complex disorder called diabetes mellitus which is associated with loss of glucose through urine and formation of harmful compounds known as ketone bodies. Insulin acts mainly on hepatocytes and adipocytes (cells of adipose tissue) and enhances cellular glucose uptake and utilisation. Due to hyposecretion of insulin, there will be increased blood sugar (hyperglycemia). Diabetic patients are successfully treated with insulin therapy. 

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