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Question

Number of ATP molecules synthesised through substrate level phosphorylation during aerobic respiration of one glucose molecule is

A
8
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B
6
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C
4
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D
2
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Solution

The correct option is B 6
Substrate level phosphorylation is a process of formation of ATP by the physical addition of phosphate group to ADP. In this process, a phosphate group is taken from an intermediate compound referred to as ADP and given to ADP. In glycolysis, 4 ATP molecules are formed as a result of substrate level phosphorylation.
1. First two ATP are formed when 1,3- diphosphoglycerate changes to 3-phosphoglycerate due to loss of phosphate group.
2. Another two ATP are formed in the last step of glycolysis when 2-phosphoenol pyruvic acid changes to pyruvic acid transferring its high energy phosphate bond to ADP.
Two ATP molecules are formed during Krebs cycle by substrate level phosphorylation when succinyl coenzyme A transfers its high energy to a phosphate group that joins GDP/ADP to form GTP/ATP.
Thus, a total of 6 ATP molecules are formed through substrate level phosphorylation during aerobic respiration of one glucose molecule.
Thus, the correct answer is option B.

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