Question

Osteoporosis, an age-related disease of skeleton system, may occur due to

• A. Decreased level of estrogen
• B. Accumulation of uric acid leading to inflammation of joints
• C. Immune disorder affecting neuro-muscular junction leading to fatigue
• D. High concentration of Ca${}^{++}$ and Na${}^{+}$

Answer 1

The correct option is A Decreased level of estrogen

Estrogen regulates osteoblast activity and stimulate bone formation. Menopause leads to lower estrogen level causing lower/no osteoblast activity. The overall effect is lower bone mass and thinning of bones which are more prone to fractures. Accumulation of uric acid leading to inflammation of joints leads to gout. Myasthenia gravis is immune disorder of neuromuscular junction that causes weakening of muscles.

Therefore, the correct answer is option A.