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Question

Some drugs do not bind the enzyme's active site, instead, bind to a different site of an enzyme. This site is called:


A
allosteric site
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B
substrate site
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C
ionic site
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D
competitive site
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Solution

The correct option is A allosteric site
A substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction.
In their catalytic activity, enzymes perform two major functions:
(i) The first function of an enzyme is to hold the substrate for a chemical
reaction. Active sites of enzymes hold the substrate molecule in a
suitable position, so that it can be attacked by the reagent effectively.
(ii) The second function of an enzyme is to provide functional groups
that will attack the substrate and carry out chemical reaction.
 Drugs inhibit any of the above mentioned activities of enzymes.
Drugs inhibit the attachment of substrate on active site of enzymes
in two different ways;
(i) Drugs compete with the natural substrate for their attachment
on the active sites of enzymes. Such drugs are called competitive
inhibitors.
(ii) Some drugs do not bind to the enzyme’s active site. These bind to a different site of enzyme which is called allosteric site. This binding of inhibitor at allosteric site changes the shape of the active site in such a way that substrate cannot
recognise it.


Biology

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