The principal buffer in interstitial fluid is

Carbonic acid

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Phosphate

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Compounds containing histidine

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Solution

The correct option is A Carbonic acid
The principal buffer in interstitial fluid is carbonic acid which is formed by the combination of carbon dioxide with water and quickly dissociates into bicarbonate ions. It neutralises the acids that are released due to metabolism.
A. Carbonic acid is the principal buffer in interstitial fluid.
B. Hb is the principal buffer in RBCs.
C. Phosphate is the buffer system in internal fluids of cells.
D. Compounds containing histidine are buffer systems in some cells.
Hence, the correct answer is 'Carbonic acid'

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