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Question

Tricarboxylic acids of Kreb's cycle are

A
Succinic acid, Fumaric acid and Citric acid
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B
Oxalosuccinic acid, Citric acid and α-ketoglutaric acid.
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C
Citric acid, Isocitric acid and Malic acid
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D
Citric acid, Isocitric acid and Oxalosuccinic acid
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Solution

The correct option is D Citric acid, Isocitric acid and Oxalosuccinic acid
Krebs cycle consists of 8 cyclic steps which begin with the reaction of two carbon compound acetyl coenzyme A (produced in glycolysis) with oxaloacetic acid (4C) in the presence of water forming 6C citric acid and freeing coenzyme A for reuse in pyruvate oxidation. The citric acid formed has 3 carboxyl groups and is known as tricarboxylic acid. Citric acid is then reorganized to form the isocitric acid (6C) which retains 3 carboxylic groups. Isocitrate undergoes dehydrogenation to form 6C oxalosuccinate. Thus all the three - citric acid, isocitric acid and oxalosuccinic acid contain 3 carboxylic acids and are called tricarboxylic acids.
Thus, the correct answer is option D.

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