Question

What is the order of the decreasing reactivity for the carboxylic acid derivatives given above, in a nucleophilic substitution reaction?

• A. II, IV, I, III
• B. III, IV, I, II
• C. IV, I, II, III
• D. I, II, III, IV

Answer 1

The correct option is A II, IV, I, III

Acid chloride is the most reactive followed by acid anhydride, then ester and amide is the most stable acid derivative. So, the order is as given above :

Hence, the correct option is A.