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Question

What would be the number of chromosomes in the ovum (fertilized by a normal sperm) that resulted in the appearance of Klinefelter's syndrome in the offspring?

A
23
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B
22
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C
21
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D
24
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Solution

The correct option is D 24
Men with Klinefelter’s syndrome have an extra X chromosome. The normal male chromosome arrangement is 46 XY, but for men with Klinefelter’s syndrome it is 47XXY. The extra X chromosome may come from the egg or sperm, or be ‘added’ early in the development of the embryo. It is not known why the extra X chromosome happens. The extra X chromosome also affects the ability to produce sperm. Men with this condition are infertile as they almost always have no sperm in their ejaculate.

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