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Question

Which of these statement is correct as per the 'Chargaff's rule'?


  1. Number of purines and pyrimidines is equal but may vary

  2. Number of purines and pyrimidines is equal universally in DNA

  3. The number of purines and pyrimidines depends on the pitch of the DNA

  4. Number of purine pairs and pyrimidine pairs is equal only in similar forms of DNA but varies from A form to B form


Solution

The correct option is B

Number of purines and pyrimidines is equal universally in DNA


Chargaff's rules states that DNA from any cell of all organisms should have a 1:1 ratio (Base Pair Rule) of pyrimidine and purine bases and, more specifically, that the amount of guanine is equal to cytosine and the amount of adenine is equal to thymine.

That is, A=T and G=C universally.

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