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Question

Which of these steps in Krebs cycle indicates substrate level phosphorylation?

A
Conversion of succinic acid to α-ketoglutaric acid
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B
Conversion of succinic acid to malic acid
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C
Conversion of succinyl CoA to succinic acid
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D
Conversion of malic acid to oxaloacetic acid
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E
Conversion of citric acid to αketoglutaric acid
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Solution

The correct option is B Conversion of succinyl CoA to succinic acid
Substrate level phosphorylation means when energy from breakdown of glucose is directly released as ATP or GTP. In Krebs cycle, only in one step GTP is released i.e., during the conversion of succinyl CoA to succinic acid. In all the other steps, energy is released as either NADH or FADH. Thus, the correct answer is option C.

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