Which one of the following reactions is an example of oxidative decarboxylation?
A
Conversion of succinate to fumarate
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B
Conversion of fumarate to malate
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C
Conversion of pyruvate to acetyl Co-A
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D
Conversion of citrate to isocitrate
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Solution
The correct option is C Conversion of pyruvate to acetyl Co-A The pyruvic acid formed during glycolysis enters the mitochondria where oxidative decarboxylation takes place and acetyl Co-A is formed from pyruvate. This reaction is catalysed by the pyruvic acid dehydrogenase complex and happens in the presence of NAD+ and coenzyme-A.