Differentiate between intrinsic and extrinsic protein


The cell membrane is also known as the plasma membrane. It is the outermost covering of animal cells. It is a semi-permeable membrane composed of lipids and proteins. Based on the existence of membrane-protein interactions, membrane proteins can be divided into two categories: integral (intrinsic) and peripheral (extrinsic). Both forms of membrane proteins are found in bio-membranes.

Intrinsic protein

  • Intrinsic protein includes those proteins that are embedded within the plasma membrane.
  • Intrinsic protein are embedded in the plasma membrane partially or completely.
  • They are more hydrophobic.

Extrinsic proteins

  • They are present in the surface of the plasma membrane
  • They are more hydrophilic and less hydrophobic

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