Explain hoffmann bromamide degradation reaction and write the general equation for reaction involved.

When an amide is treated with bromine in an aqueous or ethanolic solution of sodium hydroxide, degradation of amide leads to primary amine formation. This reaction involving the degradation of amide and is popularly known as the Hoffmann bromamide degradation reaction. The primary amine thus formed contains one carbon less than the number of carbon atoms in that amide. This is accomplished by heating the primary amide with a mixture of a halogen (chlorine or bromine), a strong base, and water. The general equation for this reaction can be illustrated as follows.

Was this answer helpful?


0 (0)

Upvote (0)

Choose An Option That Best Describes Your Problem

Thank you. Your Feedback will Help us Serve you better.

Leave a Comment

Your Mobile number and Email id will not be published. Required fields are marked *




Free Class