The Krebs cycle or Citric acid cycle is a series of enzyme catalyzed reactions occurring in the mitochondrial matrix, where acetyl-CoA is oxidized to form carbon dioxide and coenzymes are reduced, which generate ATP in the electron transport chain.
Krebs cycle was named after Hans Krebs, who postulated the detailed cycle. He was awarded the Nobel prize in 1953 for his contribution.
The Krebs cycle is also referred to as the Citric Acid Cycle, and Citric acid is the first product formed in the cycle.
It is an eight-step process.
(1) Condensation of acetyl CoA with oxaloacetate (4C) forming citrate (6C), coenzyme A is released.
(2) Conversion of Citrate to its isomer, isocitrate.
(3) Isocitrate is subjected to dehydrogenation and decarboxylation forming -ketoglutarate (5C).
(4) -ketoglutarate (5C) experiences oxidative decarboxylation, forming succinyl CoA (4C). (5) Conversion of Succinyl CoA to succinate by succinyl CoA synthetase enzyme along with substrate-level phosphorylation of GDP forming GTP.
(6) Oxidation of Succinate to fumarate by the enzyme succinate dehydrogenase.
(7) Fumarate gets converted to malate by the addition of one H2O.
(8) Malate is dehydrogenated to form oxaloacetate, which combines with another molecule of acetyl CoA and starts the new cycle.
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