How do Grignard reagents react with alcohols?

The Grignard reaction is a reaction that uses an organometallic to create this carbon-carbon bond. These reactions are called Grignard reactions. The Grignard reaction occurs with the carbon attaching to the aldehyde or ketone. Then, after adding water, we end up with a longer carbon chain attached to an alcohol. Grignard reagents are usually prepared in diethyl ether (CH3 CH2 O─CH2 CH3).

R−MgX+HO−R’→R−H+XMgOR’

  • Grignard reagents add to carbonyl compounds to give primary, secondary, and tertiary alcohols.
  • A primary alcohol is synthesized by reacting the Grignard reagent, R′─MgX, with formaldehyde.
  • Reacting a Grignard reagent with an aldehyde gives a secondary alcohol. Reacting a Grignard reagent with a ketone gives a tertiary alcohol.

Leave a Comment

Your email address will not be published. Required fields are marked *

BOOK

Free Class