In 1953, Watson and Crick proposed a DNA double helix model for which they won the Nobel Prize. Their model of DNA was based on:

(A) Chargaff’s base equivalence rule

(B) Griffith’s transformation experiment

(C) X-ray diffraction studies of DNA done by Wilkins and Franklin

(D) Both (A) and (C).

The Correct Answer is (D) Both (A) and (C).

Solution

In 1953, James Watson and Francis Crick, based on the X-ray diffraction data produced by Maurice Wilkins and Rosalind Franklin, proposed a double helix model for the structure of DNA. One of the hallmarks of their proposition was base pairing between the two strands of polynucleotide chains. However, this proposition was also based on Erwin Chargaff’s (1950) observation that for a double-stranded DNA, the ratios between Adenine and Thymine and Guanine and Cytosine are constant and equal.

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