Question

Non-competitive inhibitor changes the active site of the enzyme after binding at___________.

Answer 1

Allosteric site:

1. An inhibitor molecule binds to the enzyme in the allosteric site, which is different from the active site, in non-competitive inhibition.
2. Although the inhibitor alters the shape of the enzyme, the substrate can still bind to it, but the enzyme is no longer in a good position to catalyze the reaction.
3. In the case of competitive inhibition, an inhibitor molecule that is sufficiently similar to a substrate can attach to the active site of the enzyme and prevent it from binding to the substrate.
4. In order to bind to the enzyme, it "competes" with the substrate.

Final answer: Non-competitive inhibitor changes the active site of the enzyme after binding at the allosteric site.