What are modified amino acid? Give Examples.

Modified amino acids are derived from a single amino acid. Modified amino acids are in-house manufactured amino acid derivatives with specific properties enabling the intensification of cell culture processes. Both modified amino acids eliminate the need for alkaline feeds, which are normally applied to ensure solubility and balance of the unmodified amino acids tyrosine and cysteine. The utilization of just one single, neutral pH feed is a revolutionary idea to simplify fed-batch processes.

Uses of modified amino acids

  • The use of modified amino acids can furthermore have positive impacts on cell culture duration or productivity.
  • The high feed concentration possible using modified amino acids allows to lower the feed volume addition in biopharmaceutical manufacturing and thus may bring an increase in titer.
  • Together, Phospho-L-Tyrosine disodium salt and S-Sulfocysteine sodium salt can be practised as a replacement for tyrosine and cysteine to generate highly concentrated, neutral pH feeds.

Articles to explore

  1. How are amino acids classified?
  2. What are amino acids?

 

 

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