Write a short note on the denaturing and folding of proteins

In protein, the polypeptide chains fold during and following synthesis to take up its native conformation. Properties of the protein very much depend on the confirmation (three-dimensional structure). The native protein conformation is only marginally stable such that even modest changes in the environment can bring about structural changes that can affect function. Loss of three-dimensional structure (secondary, ternary and quaternary but not the primary structure) sufficient to cause loss of function is called denaturation. Under most conditions, denatured proteins exist in a set of partially folded states that are poorly understood. Example: The coagulation of eggs upon boiling and the curdling of milk upon the addition or formation of acid.

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