Methylene blue - C16H18ClN3S

What is Methylene blue (C16H18ClN3S)?

Methylene blue is an organic chloride salt with a formula C16H18ClN3S. It is also called Methylthioninium chloride or Swiss Blue. It is a thiazine dye with antioxidant, cardioprotective properties, antimalarial, and an antidepressant. It is soluble in glycerol, water, chloroform, glacial acetic acid, and ethanol. It is slightly soluble in pyridine and insoluble in ethyl ether, oleic acid, and Xylene.

It is a synthetic basic dye. When its administration route is intravenously and in low doses, it converts methemoglobin to haemoglobin. It functions as a histological dye, tracer, acid-base indicator, neuroprotective agent, fluorochrome, etc.

This compound was first synthesized by Heinrich Caro in the year 1876. It is obtained as a dark green crystalline powder or crystal with a bronze-like lustre. When dissolved in an alcohol solution or water it gives a deep blue colour. It is widely used in treating methemoglobin levels greater than 30%.

Properties of Methylene blue – C16H18ClN3S

Methylene blue C16H18ClN3S
Molecular Weight of Methylene blue 319.85 g/mol
Trade names Urelene blue, Proveblue, Provable
Melting Point of Methylene blue 100 to 110 °C
Routes of administration Mouth and IV

Structure of Methylene blue (C16H18ClN3S)

Structure of Methylene blue

Uses of Methylene blue (C16H18ClN3S)

  • Methylene blue is used as an indicator
  • It is used as a bacteriologic stain.
  • Used to lower levels of Methemoglobin.
  • It is combined with light and used in the treatment of resistant plaque psoriasis.
  • It is used to identify dysplasia.

Effects on Health

Common side effects include headache, vomiting, high blood pressure, confusion, allergic reactions, shortness of breath, red blood cell breakdown, serotonin syndrome. Using this turns the urine, stool, and sweat, blue to green in colour. It converts the ferric iron present in the haemoglobin to ferrous iron.

Learn more about the physical and chemical properties of Methylene blue (C16H18ClN3S) from the experts at BYJU’S.

Leave a Comment

Your email address will not be published. Required fields are marked *