Difference between CDS and cDNA

CoDing sequences (CDS) are regions of RNA or DNA whose sequence determines the sequence of amino acids in a given protein. cDNA (complementary DNA) contains exons or coding regions. It is synthesized from RNA (such as mRNA or microRNA), the single-stranded template in a reaction; catalysis by the reverse transcriptase enzyme. Often, in prokaryotes, cDNA finds its application to clone eukaryotic genes.

CDS (coding DNA sequence)

  • CDS (coding DNA sequence) is the coding region of a gene. It is the part of a gene of DNA or RNA which codes for a particular protein
  • The term is interchangeably used with exon, however, it is not the exact same. Exons comprise coding regions and 3′ and 5′ untranslated regions of the RNA. As a result, the exons would partly be composed of coding regions
  • The 3′ and 5′ untranslated parts of the RNA that do not code for proteins are the non-coding areas

cDNA

  • cDNA (Complementary DNA) are copies of mRNA (a messenger RNA) molecule produced by the reverse transcriptase, which is a DNA polymerase that can use either RNA or DNA as templates
  • These are synthesized from a single-stranded mRNA or microRNA template
  • These are also naturally produced by the retrovirus and then integrated into the genome of the host where a provirus is created

Key Difference between CDS and cDNA

The table below depicts the difference between CDS and cDNA.

CDS

cDNA

What is it?

These are regions of RNA or DNA whose sequence determines the sequence of amino acids in a protein

These are sequences of DNA obtained from mRNA through the process of the reverse transcription

Composition

Exons and codons

The sequence of mRNA and 2 UTRs

Is the process of synthesis natural?

Yes

No, artificial

Are untranslated regions included?

No

Yes

How is it synthesized?

Each individual’s genomic DNA has CDS

Artificially, synthesis is carried out from mRNA through the process of the reverse transcription

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