MCQs on Antibiotics

  1. What is the pH of the fermentation medium for chlortetracycline?
  2. (a) 2-3

    (b) 3-4

    (c) 5-6

    (d) 8-9

    Sol. (c) 5-6.

  3. The yield of the antibiotic depends upon __________.
  4. (a) Age of the inoculum

    (b) Only the pH of the medium

    (c) Composition of the medium

    (d) All of the above

    Sol. (d) All of the above.

  5. In Penicillium chrysogenum, the maximum antibiotic production occurs during the __________.
  6. (a) The second phase

    (b) Third phase

    (c) First phase

    (d) In all three phases

    Sol. (a) The second phase.

  7. The fermentation medium for oxytetracycline consists of__________.
  8. (a) CSL, Ammonium sulfate, sodium chloride and Calcium carbonate

    (b) CSL, Ammonium sulfate, ammonium chloride and Calcium carbonate

    (c) CSL, starch, Ammonium sulfate, sodium chloride and Calcium carbonate

    (d) CSL, starch, Ammonium sulfate, ammonium chloride and Calcium carbonate

    Sol. (d) CSL, starch, Ammonium sulfate, ammonium chloride and Calcium carbonate.

  9. At normal the pH value of penicillin remains in__________.
  10. (a) Solvent phase

    (b) Precipitates

    (c) Aqueous phase

    (d) Both (a) and (b)

    Sol. (c) Aqueous phase.

  11. In which of the following substances is chlortetracycline soluble?
  12. (a) Water

    (b) Ether

    (c) Organic solvents

    (d) All of the above

    Sol. (a) Water.

  13. Which of the following statements are true about penicillin at acidic pH?
  14. (a) Penicillin precipitates

    (b) Penicillin remains in the aqueous phase

    (c) Penicillin remains in the solvent phase

    (d) None of the above

    Sol. (c) At acidic pH penicillin remains in the solvent phase.

  15. Which of the following fermentation processes is used in the production of penicillin?
  16. (a) Aerobic fermentation followed by anaerobic fermentation

    (b) Anaerobic fermentation

    (c) Aerobic fermentation

    (d) Anaerobic fermentation followed by aerobic fermentation

    Sol. (c) Aerobic fermentation.

  17. Which of the following is the media composition for the production of streptomycin?
  18. (a) Glucose, soybean meal, malt extract, ammonium chloride

    (b) Calcium carbonate, soybean meal, glucose, peptone

    (c) Ammonium sulphate, soybean meal, peptone, malt extract.

    (d) Soybean meal, glucose, peptone, malt extract, sodium chloride

    Sol. (d) Soybean meal, glucose, peptone, malt extract, sodium chloride.

  19. Which of the following media composition is used for the production of chlortetracycline?
  20. (a) Calcium Carbonate, Sugar and Ammonium sulfate

    (b) Corn steep liquor, Calcium Carbonate, and Ammonium sulfate

    (c) Corn steep liquor, Ammonium Chloride. , Calcium Carbonate, and Ammonium sulfate

    (d) Sugar, corn steep liquor, Calcium Carbonate, Ammonium sulfate, and Ammonium Chloride.

    Sol. (d) Sugar, corn steep liquor, Calcium Carbonate, Ammonium sulfate, and Ammonium Chloride.

  21. After the fermentation process, penicillin is recovered as
  22. (a) Penicillin

    (b) Sodium penicillin

    (c) Calcium penicillin

    (d) Potassium penicillin

    Sol. (d) Potassium penicillin.

  23. Which of the following species is used for producing streptomycin?
  24. (a) S. ramosus

    (b) S. griseus

    (c) S. aerofaciens

    (d) S. griseoflavus

    Sol. (b) S. griseus.

  25. The high yield of chlortetracycline requires ____________.
  26. (a) No aeration

    (b) Controlled aeration

    (c) Continuous aeration

    (d) Aeration which does not affect the yield

    Sol. (c) Continuous aeration.

  27. Which of the following statements are true about the vegetable oil added in the fermentation medium for penicillin?
  28. (a) It acts as a carbon source

    (b) It acts as an antifoam agent

    (c) It acts as a source of nutrients

    (d) All of the above

    Sol. (b) It acts as an antifoam agent.

  29. Which of the following events occurs during the second phase of growth of Penicillium chrysogenum?
  30. (a) pH increase

    (b) Mycelial mass increases

    (c) Both (a) and (b)

    (d) Synthesis of penicillin is high

    Sol. (c) Both (a) and (b).

  31. Which of the following seeds are used for the inoculum preparation for the fermentation medium for penicillin?
  32. (a) Rice seeds

    (b) Corn seeds

    (c) Wheat seeds

    (d) Barley seeds

    Sol. (d) Barley seeds.

  33. Which of the following antibiotics are most likely responsible for hypotension, itching and other side effects?
  34. (a) Aztreonam

    (b) Vancomycin

    (c) Daptomycin

    (d) Linezolid

    Sol. (b) Vancomycin.

  35. Which of the following events occurs during the first phase of growth of Penicillium chrysogenum?
  36. (a) A maximum rate occurs by the utilization of lactic acid present in the corn steep liquor

    (b) Growth of mycelia

    (c) Ammonia is liberated in the medium

    (d) All of the above

    Sol. (d) All of the above.

  37. What type of side effect is most commonly observed in beta-lactam antibiotics?
  38. (a) Hearing loss

    (b) Aplastic anaemia

    (c) Allergic reaction

    (d) Yellowing of teeth

    Sol. (c) Allergic reaction.

  39. Which of the following events occurs during the third phase of growth of Penicillium chrysogenum?
  40. (a) Autolysis of the medium starts

    (b) Slight rise in pH due to liberation of ammonia

    (c) The concentration of antibiotic increases in the medium

    (d) All of the above

    Sol. (d) All of the above.

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