Curtius Rearrangement

Curtius Rearrangement

What is Curtius Rearrangement?

Curtius Rearrangement is also called Curtius degradation or Curtius reaction. Curtius Rearrangement is a thermal decomposition of acyl acid to form isocyanate with a loss of nitrogen as stated by Theodor Curtius in the year 1885. It is also known as Curtius degradation or Curtius reaction. This reaction is identical to Schmidt Reaction.

Isocyanates are subjected to attack by various nucleophiles namely alcohols, water, and amines which in turn outputs urea derivative or carbamate and essential amines.

Mechanism of Curtius Rearrangement

  • Acyl azide preparation

Curtius Rearrangement

  • DecompositionCurtius Rearrangement
  • Reacts with water to form an unstable carbamic acid derivative. It further undergoes spontaneous decarboxylation.Curtius Rearrangement
    Curtius Rearrangement
  • Isocyanates are versatile starting materials. Isocyanates play a vital role in polymerization work and in the derivatization of biomacromolecules.
    Curtius Rearrangement Stay tuned with Byju’s to learn more interesting topics in Chemistry. Also, get various engaging and video lessons to learn more effectively.

Practise This Question

In an atom, an electron is moving with a speed of 600 m/s with an accuracy of 0.005 %. Certainity with which the position of the electron can be located is

(h = 6.6 × 1034 kg m2 s1,mass of electron, em = 9.1 × 1031 kg)