Are Spindles Bipolar?
All spindles are bipolar, however, the structure of the poles vary in different entities. In the majority of the somatic... View Article
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What Is Bi-orientation?
Although some features of spindle structure vary in different organisms, the underlying logic is always the same. The microtubule array... View Article
Do Sister Chromatids Participate In Spindle Assembly?
The sister chromatids actively are involved in spindle assembly and the function. Each chromatid carries a kinetochore, a multiprotein complex... View Article
What Does The Mitotic Spindle Depend On?
The mitotic spindle depends on a bipolar array of microtubules, each is a polarized protein polymer with one end, the... View Article
What Is The Role Of Cohesin Complexes In Species?
The regulation of chromosome condensation may depend in some species on sister-chromatid cohesion. In budding yeast, where cohesin is bound... View Article
Why Is Condensin II Positioned To Initiate Chromosome Condensation In Prophase?
The steps in chromosome condensation in vertebrate cells, can be regulated, in part at least, by condensin localization in cells.... View Article
What Do Mitotic Changes In Chromosomes Depend On?
In the chromosome structure, mitotic changes are based on coordinated changes in the chromosome compaction, incomplete loss of sister-chromatid cohesion... View Article
Are Condensins Required For Sister-chromatid Resolution?
Though learnt through its role in the condensation of chromosomes, condensins are needed for sister-chromatid resolution. In condensin proteins, mutations... View Article
What Was The Basis For The Discovery Of The Condensin Complex?
The condensin complex first was discovered based on its ability to facilitate chromosome condensation in the extracts of the eggs... View Article
What Is The Outcome Of Condensation In Animal Cells?
In animal cells, where chromosomes are specially long, condensation leads to a 10,000-fold decrease in the length of the chromosome.... View Article
Are Sister Chromatids Formed At The Completion Of The S Phase?
When the S phase is complete, the cell contains several sister-chromatid pairs that form a fragile mass of tangled DNA... View Article
For How Long Does DNA Decatenation Extend?
A central purpose of mitosis is to distribute the duplicated sister chromatids into two daughter nuclei. This clearly requires chromatid... View Article
In Which Phase Does The Cohesin Linkage Between Sister Chromatids Get Established?
Between sister chromatids, the cohesin linkage is set up during the S phase and appears to be closely tied to... View Article
What Are SMC Proteins?
SMC (structural maintenance of chromosomes) proteins are a family of large proteins composed of a long coiled-coil region with a... View Article
What Are The Two Mechanisms Involved In Sister-chromatid Cohesion?
At least two mechanisms are involved in sister-chromatid cohesion. The first, DNA catenation, is the large interweaving of the duplicated... View Article
Why Should DNA Molecules Of Eukaryotic Chromosomes Be Rapidly Copied?
The giant DNA molecules of eukaryotic chromosomes need to be copied rapidly to ensure that replication is completed in a... View Article
What Are Negative Feedback Oscillators?
Regulatory networks that depend in some way on a negative feedback loop are often capable of generating repeated oscillations in... View Article
What Is Ubiquitination?
Cyclins, Cdk inhibitor proteins and other cell-cycle regulators are targeted for degradation by the attachment of multiple copies of the... View Article
What Is A Hydrophobic Patch?
The substrate specificity of S cyclins depends on a region called the hydrophobic patch, which lies on the surface of... View Article
What Is A Double Thymidine Block?
Double thymidine block – It is a method for synchronously arresting a mammalian cell population at the beginning of the... View Article
