Difference between Globin and Globulin


Globins are globular proteins that have a heme-group to bind and transport oxygen. It is a superfamily of proteins that have a three-dimensional fold. They are found in most organisms. Examples – Hemoglobin, myoglobin, cytoglobin, neuroglobin, Globin E, androglobin, etc. All these are water soluble proteins.


Globulins are also globular proteins. They are insoluble in pure water. They form a major component of blood protein along with fibrinogen and albumins. The normal globulin concentration is 2.6-4.6 g/dL in human blood. Alpha globulins, beta globins, gamma globulins and immunoglobulins are some types of globin molecules.

They help in transporting metals and metabolites. The immunoglobulins or antibodies are a type of gamma globulins that are immunologically active.

Extended Reading: Immunoglobulins

Difference between Globin and Globulin



It is a large protein with several polypeptides.

It is a simpler protein molecule.

They are involved in the binding and transportation of oxygen.

They transport metals and metabolites. Also, they are involved in immune responses.

They are mostly soluble in water.

They are insoluble in pure water.

Myoglobin, Hemoglobin, Androglobin, Neuroglobin, Globin E, and Cytoglobin are some globin molecules.

Alpha, Beta and Gamma globulins are the three major types. Immunoglobulins come under the gamma globulins.

Also Read: Differences between Hemoglobin and Myoglobin.

Frequently Asked Questions


What are globular proteins?

They are globular or spherical proteins that act as enzymes or messengers. They also help in the transportation of molecules. The well known globular proteins are globins (e.g., hemoglobin), globulins (e.g., immunoglobulins) and albumins. Most of the globular proteins are water soluble.

What are pseudoglobulins?

They are a category of globulins that are soluble in pure water. They are even more soluble in an ammonium sulphate solution. Also, there is another category of globulins called euglobulins that are insoluble in pure water.


What is gluten?

Gluten is a type of protein seen in cereals like wheat, rye, oats and barley. It is composed of gliadins and glutenins. This naturally occurring protein can trigger inflammatory responses in some people.

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