Correct chromosome attachment in meiosis, as in mitosis, is thought to be achieved by a trial and error process whereby only the correct... View Article
In budding yeast, the monopolar attachment of the two sister kinetochores depends on a group of proteins called the monopolins. If a mutation... View Article
The response to recombination defects is mediated by a recombination checkpoint system that is analogous to the checkpoint systems controlling... View Article
The first main regulatory transition of the meiotic program takes place in late G1, when the diploid cell becomes committed to the meiotic S... View Article
Electron micrographs of the synaptonemal complex disclose that many particles called early recombination nodules are found between the homologs... View Article
The main structural constituent of the synaptonemal complex is a double row of protein filaments bridging the gap between homologs referred to as... View Article
The role of crossover sites is a significant regulatory event as it regulates the number of chiasmata holding the homologs together at the end of... View Article
Towards the end of leptotene, the homologs are aligned closely by many interaxis bridges which are thought to correspond to sites where DNA... View Article
In zygotene, the homologs come in proximity, to a distance of about 100 nm, in a phenomenon called synapsis. An array of protein filaments called... View Article
Meiotic DNA recombination comes along with distinct modifications in the structure of the chromosomes that are prominent readily when viewed... View Article
At some sites which are designated to become crossovers, a different sequence of events unfolds. The first detectable step in this sequence is... View Article
Meiotic recombination begins when both strands of the DNA double helix are cleaved at many locations by the enzyme Spo11. The exposed DNA 5' ends... View Article
There are two main outcomes - Either a non-crossover event which aids in facilitating homolog pairing, however, it does not produce a lasting... View Article
In the meiotic prophase, homologous chromosomes where each is identified by a sister-chromatid pair—become linked together in preparation... View Article
In multicellular organisms, entry into the meiotic program occurs only in a small population of cells, called the germline, which are the... View Article
Defects in the meiotic chromosome segregation are infrequent in most of the entities however, more frequent in humans, as they can cause gametes... View Article
Although homologs are separated, cohesion between sister-chromatid pairs is maintained at the centromeres throughout the first meiotic division.... View Article
Chiasmata hold homologs together in meiosis I only as the sister-chromatid arms distal to the chiasmata (that is, on the side away from the... View Article
After the meiotic prophase, homolog pairs become bi-oriented on the first meiotic spindle. As each homolog comprises two sister chromatids, there... View Article
The events of the meiotic prophase are accompanied by chromosomal changes that are visible under the microscope. In the early prophase,... View Article
