Cell growth is the phenomena wherein a cell increases its size by synthesizing the proteins, membranes, organelles and other components that make... View Article
The rate of cell division is governed by a combination of intracellular and extracellular factors. Yeast proliferation is limited primarily by... View Article
After meiosis II, haploid nuclei are packaged into cells that differentiate into specialized cell types, such as spores in yeast or gametes... View Article
DNA synthesis is a vital event that must take place after mitosis, however, must never occur after meiosis I. Robust mechanisms are present to... View Article
The mechanisms driving the completion of meiosis I is related to but distinct from those controlling the completion of mitosis. As in mitosis,... View Article
The separation of the homologs in the first meiotic division is immediately followed by entry into meiosis II. As in mitosis, the central... View Article
The pulling forces of the meiotic spindle at metaphase I are opposed only by sister-chromatid arm cohesion distal to the chiasmata. Anaphase I is... View Article
It is the ability of one crossover to suppress the formation of other crossovers in the vicinity. It could facilitate the effectiveness of... View Article
Effective homolog linkage depends on the positioning of chiasmata along the chromosomes. If homologs are linked by a single chiasma that is very... View Article
Accurate chromosome alignment in meiosis I require connections between homolog pairs. In most species, this linkage depends on the chiasmata that... View Article
Correct chromosome attachment in meiosis, as in mitosis, is thought to be achieved by a trial and error process whereby only the correct... View Article
In budding yeast, the monopolar attachment of the two sister kinetochores depends on a group of proteins called the monopolins. If a mutation... View Article
The response to recombination defects is mediated by a recombination checkpoint system that is analogous to the checkpoint systems controlling... View Article
The first main regulatory transition of the meiotic program takes place in late G1, when the diploid cell becomes committed to the meiotic S... View Article
Electron micrographs of the synaptonemal complex disclose that many particles called early recombination nodules are found between the homologs... View Article
The main structural constituent of the synaptonemal complex is a double row of protein filaments bridging the gap between homologs referred to as... View Article
The role of crossover sites is a significant regulatory event as it regulates the number of chiasmata holding the homologs together at the end of... View Article
Towards the end of leptotene, the homologs are aligned closely by many interaxis bridges which are thought to correspond to sites where DNA... View Article
In zygotene, the homologs come in proximity, to a distance of about 100 nm, in a phenomenon called synapsis. An array of protein filaments called... View Article
Meiotic DNA recombination comes along with distinct modifications in the structure of the chromosomes that are prominent readily when viewed... View Article
