The pace of cell division is regulated by a combination of extracellular and intracellular factors. Yeast proliferation is limited primarily by... View Article
When environmental conditions are ideal, yeast and other unicellular organisms reproduce as rapidly as possible, progressing from one cell cycle... View Article
Centrosome duplication is completely uncoupled from DNA duplication in some cell types. In the endocycling cells of Drosophila larvae, for... View Article
It is important that the cell enters mitosis with precisely two centrosomes. Cells containing abnormal numbers of centrosomes tend to have... View Article
Centrosome duplication is largely complete by the beginning of mitosis, although the new centriole is not completely finished until late mitosis.... View Article
The centrosome of animal cells is located in the cytoplasm just outside the nuclear envelope. The centrosome contains a pair of structures,... View Article
A microtubule behavior also results from the higher rate of tubulin association at the plus end than at the minus end. At some concentrations of... View Article
As all the tubulin dimers in a filament are aligned in the same way, the two ends of a microtubule are structurally different. One of the ends... View Article
The construction of a bipolar spindle in all eukaryotes is largely based on the ability of the spindle elements to organize on their own. Motor... View Article
All spindles are bipolar, however, the structure of the poles vary in different entities. In the majority of the somatic animal cells, each of... View Article
Although some features of spindle structure vary in different organisms, the underlying logic is always the same. The microtubule array should be... View Article
The sister chromatids actively are involved in spindle assembly and the function. Each chromatid carries a kinetochore, a multiprotein complex... View Article
The mitotic spindle depends on a bipolar array of microtubules, each is a polarized protein polymer with one end, the 'minus end', implanted in a... View Article
The regulation of chromosome condensation may depend in some species on sister-chromatid cohesion. In budding yeast, where cohesin is bound to... View Article
The steps in chromosome condensation in vertebrate cells, can be regulated, in part at least, by condensin localization in cells. In prophase,... View Article
In the chromosome structure, mitotic changes are based on coordinated changes in the chromosome compaction, incomplete loss of sister-chromatid... View Article
Though learnt through its role in the condensation of chromosomes, condensins are needed for sister-chromatid resolution. In condensin proteins,... View Article
In animal cells, where chromosomes are specially long, condensation leads to a 10,000-fold decrease in the length of the chromosome. Condensation... View Article
