23 April 2024 CNA
Download PDF Here
TABLE OF CONTENTS
A. GS 1 Related B. GS 2 Related C. GS 3 Related SCIENCE AND TECHNOLOGY 1. The tools helping scientists up the rate at which they find new drugs D. GS 4 Related E. Editorials ENVIRONMENT 1. Restoring earth’s right to ‘good health’ DISASTER MANAGEMENT 1. A lesson from Taiwan in quake resilience POLITY 1. What are rules around star campaigners? F. Prelims Facts 1. Venkaiah Naidu, Mithun Chakraborty, Usha Uthup, Ram Naik conferred Padma awards 2. With a dip in voter turnout in the first phase, ECI forms a task force to oversee heat wave conditions 3. Two women Navy officers return after a historic transoceanic expedition G. Tidbits H. UPSC Prelims Practice Questions I. UPSC Mains Practice Questions
A. GS 1 Related
Nothing here for today!!!
B. GS 2 Related
Nothing here for today!!!
C. GS 3 Related
Category: SCIENCE AND TECHNOLOGY
1. The tools helping scientists up the rate at which they find new drugs
Syllabus: Developments in Science and Technology, Applications of scientific developments in everyday life
Mains: Challenges faced by India in manufacturing antimicrobial drugs
Context​:
- The journey from identifying potential drug targets to developing effective drugs is crucial yet challenging.Â
- As drug-target discovery advances, attention shifts towards the tools and expertise needed for drug development.Â
- This includes molecular docking simulations, chemical libraries, structural and computational biologists, and institute-industry collaborations.Â
- India, a leading manufacturer and consumer of antimicrobial drugs, faces challenges due to the increasing ineffectiveness of these drugs, resulting in millions of deaths worldwide.
Initiating Drug Discovery
- Researchers at CSIR-Centre for Cellular and Molecular Biology, Hyderabad, identified potential targets for new antimalarial drugs by studying Escherichia coli and Plasmodium falciparum.
- Manjula Reddy’s group focused on peptidoglycan hydrolase enzymes in E. coli, essential for bacterial survival.
- Puran Singh Sijwali’s group identified enzymes crucial for the development of P. falciparum.
Steps in Drug Discovery
- Drug discovery typically starts with finding inhibitor molecules that bind to a target and block its function.
- Structural information of target molecules is crucial, but obtaining structures for large molecules like those studied by Dr. Sijwali’s group is challenging.
- Molecular docking simulations help predict how well small drug-like compounds bind to target molecules.
- Various chemical libraries, including FDA-approved drugs and research institute compounds, aid in drug discovery.
Role of Artificial Intelligence
- AI-driven programs can predict structures of potential drug molecules, aiding in drug discovery.
- Collaboration between researchers and pharmaceutical companies facilitates the synthesis and testing of potential drug candidates.
Challenges in Drug Discovery
- Testing potential drugs for safety and efficacy involves cell culture and animal models.
- Clinical trials are rigorously regulated to ensure ethical conduct and unbiased data.
- Drug discovery requires collaboration among experts from multiple disciplines, sufficient funding, and access to advanced tools and facilities.
Significance
- Accelerating drug discovery is essential to combat antimicrobial resistance and address global health challenges.
- Collaboration between researchers, startups, and the industry is crucial for leveraging expertise and resources.
Solutions
- Enhanced collaboration between infectious disease biologists, structural biologists, computational biologists, chemists, and research institutions can streamline drug discovery processes.
- Leveraging tools such as molecular docking simulations, AI-driven drug discovery, and chemical libraries can expedite the identification of potential drug candidates.
Nut Graf: Drug discovery is a complex yet necessary process in addressing global health challenges. By leveraging advanced tools, interdisciplinary collaboration, and innovative approaches, researchers can accelerate the development of life-saving drugs to combat infectious diseases. The research and innovation community must unite, utilize available techniques and facilities, and prioritize drug discovery efforts to benefit local and global communities.
D. GS 4 Related
Nothing here for today!!!
E. Editorials
Category: ENVIRONMENT
1. Restoring earth’s right to ‘good health’
Syllabus: Conservation
Mains: Right-based conservation approach
Context:
- Landmark decisions by the European Court of Human Rights and the Supreme Court of India highlight the intersection of climate crisis and human rights.
- Courts recognize inadequate government actions as violations of citizens’ rights to protection from climate change impacts.
- Climate change is increasingly viewed as a human rights crisis worldwide.
Urgent Need for Climate Action:
- The latest State of the Global Climate Report underscores the severity of climate change effects, with 2023 being the hottest year on record.
- Rising temperatures, natural disasters, and environmental stressors threaten people’s health, livelihoods, and socioeconomic equality.
- The UN Secretary-General emphasizes the urgent need to restore harmony with nature to ensure humanity’s well-being.
India’s Climate Action and Vulnerabilities:
- India, a rapidly growing economy, has made strides in decoupling emissions from economic growth and achieving NDC targets ahead of schedule.
- Despite progress, India remains highly vulnerable to climate change, with over 80% of its population residing in climate disaster-prone areas.
- Climate impacts exacerbate existing socio-economic inequalities and pose significant challenges to livelihoods and food security.
Pathways for Accelerated Climate Action:
- Adoption of an overarching regulation on climate change can enhance state capacities, drive the allocation of resources, and facilitate more ambitious climate action.
- Learning from successful climate change framework laws in other countries, India can strengthen climate governance and promote knowledge exchange.
- Leveraging India’s localisation model for SDGs can integrate climate action into local-level planning, fostering innovation and collaboration among stakeholders.
Conclusion:
- By leveraging legal precedents, India can empower citizen groups, foster rights-based dialogues on climate action, and restore Mother Earth’s right to good health.
- Upholding nature’s rights and protecting against climate change impacts are essential for ensuring a sustainable and equitable future for all.
Nut Graf: Legal rulings recognize climate change as a human rights crisis. Urgent action is needed as global indicators worsen. India’s progress is marred by vulnerability. Strategic pathways can accelerate climate action, restoring balance with nature and protecting human rights.
Category: DISASTER MANAGEMENT
1. A lesson from Taiwan in quake resilience
Syllabus: Disaster and Disaster Management
Mains: Taiwan model of Earthquake resilience
Introduction:
- Earthquakes have struck various regions globally in the past two decades, including Taiwan, Nepal, India, and many others.
- The distribution of earthquakes is explained by plate tectonics, where Earth’s plates constantly move, leading to seismic activity along their boundaries.
- Notable examples include earthquakes along the Himalayas due to the convergence of the Indian and Eurasian plates.
Taiwan’s Earthquake History:
- Taiwan sits at the convergence of the Philippine Sea and Eurasian plates, making it prone to earthquakes.
- The 1999 Chi-Chi earthquake and the 2024 Hualien earthquake, both of significant magnitude, demonstrate Taiwan’s vulnerability.
- Despite similar magnitudes, the 2024 earthquake caused minimal damage compared to its predecessor.
Lessons from Taiwan’s Resilience:
- The 1999 Chi-Chi earthquake prompted Taiwan to enact administrative reforms, leading to improved emergency response and disaster reduction.
- Stringent building codes implemented post-1999 earthquake significantly reduced damage in the 2024 earthquake.
- Taiwan boasts advanced earthquake preparedness, including robust monitoring networks, early warning systems, and public awareness campaigns.
- Continuous updates to building codes and incentives for residents to enhance building resilience contribute to Taiwan’s earthquake readiness.
Implications for India and Recommendations:
- India’s infrastructure expansion in earthquake-prone regions, like the Himalayas, necessitates strict adherence to seismic safety regulations.
- Learning from Taiwan’s example, India should enforce seismic codes, construct engineered structures, and address enforcement gaps.
- Localized seismic codes, tailored to regional seismic activity and construction materials, are crucial for India’s earthquake resilience.
- Rediscovering and promoting traditional architectural styles with inherent earthquake resistance can complement modern engineering approaches in India.
Nut Graf: Taiwan’s earthquake resilience, exemplified by minimal damage in the 2024 Hualien quake, offers crucial lessons for earthquake-prone regions like India. Emphasizing stringent building codes and public awareness can significantly enhance disaster preparedness.
Category: POLITY
1. What are rules around star campaigners?
Syllabus: Salient Features of the Representation of People’s Act
Mains: About Star campaigners
Introduction: Representation of the People Act, 1951 (RP Act)
- Section 77 of the RP Act governs expenditure incurred by ‘leaders of a political party’, also known as star campaigners.
- Recognized political parties can appoint up to 40-star campaigners, while unrecognised parties can appoint up to 20.
- Names of star campaigners must be communicated to the Election Commission and Chief Electoral Officer within seven days of election notification.
- Separate lists can be submitted for different phases of multi-phase elections.
Benefits for Star Campaigners:
- Expenditure incurred by star campaigners for travel or transport during campaigning is not counted towards a candidate’s election expenditure.
- This allows candidates to benefit from the campaign efforts of star campaigners without exceeding their expenditure limits.
Election Commission Advisory:
- The Election Commission has issued advisories to maintain decorum and raise the level of debate on issues during campaigning.
- Star campaigners have been cautioned against violations, such as using inappropriate language or appealing to caste/communal sentiments.
Instances of Violations and Court Rulings:
- Instances like Anurag Thakur and Parvesh Verma’s removal from star campaigners list in Delhi due to inflammatory remarks, and the Supreme Court’s stay on Kamal Nath’s removal in Madhya Pradesh, highlight the challenges in enforcing regulations.
- Assessment of expenditure for rallies/meetings involving star campaigners often falls short, raising concerns about accurate apportionment of expenses to candidates.
Proposed Solutions:
- Amendment to Empower Election Commission:
- Amend the law to authorize the Election Commission to revoke star campaigner status in case of serious violations of the Model Code of Conduct.
- This could ensure greater accountability among campaigners and promote responsible campaigning.
- Improved Assessment Procedures:
- Enhance the assessment and apportionment of expenses for rallies/meetings involving star campaigners to reflect current market rates accurately.
- This would address discrepancies and ensure fair distribution of expenses among candidates.
Nut Graf: The Representation of the People Act, 1951 regulates star campaigners’ expenditure. Despite benefits like exemption from candidate expenditure limits, issues persist, prompting calls for empowering the Election Commission and improving expense assessment procedures.
F. Prelims Facts
1. Venkaiah Naidu, Mithun Chakraborty, Usha Uthup, Ram Naik conferred Padma awards
Context: The Padma Awards, one of the highest civilian honours in India, were recently conferred upon several prominent personalities by President Droupadi Murmu. Among the recipients were former Vice-President M. Venkaiah Naidu, actor-turned-politician Mithun Chakraborty, singer Usha Uthup, and tennis player Rohan Bopanna. The awards recognize individuals from various fields who have made significant contributions to society.
Padma Vibhushan Awardees
- Former Vice-President M. Venkaiah Naidu, Bharatanatyam dancer Padma Subrahmanyam and Sulabh International’s founder Bindeshwar Pathak were conferred with Padma Vibhushan. Pathak received the prestigious award posthumously, with his wife, Amola, accepting it on his behalf.
Padma Bhushan Awardees
- Actor-politician Mithun Chakraborty, singer Usha Uthup, former Uttar Pradesh Governor Ram Naik, and industrialist Sitaram Jindal were among the Padma Bhushan recipients.
- Notable recipients also included Gujarat-based cardiologist Tejas Madhusudan Patel, veteran Marathi film director Dattatray Ambadas Mayaloo, alias Rajdutt, and physician Chandreshwar Prasad Thakur for his contributions to research and policy on Kala Azar.
Padma Shri Awardees
- Padma Shri awardees encompassed individuals from diverse fields such as carpet weaving, folk singing, and embroidery.
- Khalil Ahamad, a master carpet weaver from Uttar Pradesh, folk singer Kaluram Bamaniya from Madhya Pradesh, Bangladeshi singer Rezwana Choudhury Bannya, and Chikankari embroidery artist Naseem Bano from Uttar Pradesh were among the recipients.
Significance
- The Padma Awards serve to recognize and honour individuals who have excelled in their respective fields and contributed significantly to society.
- They inspire others to strive for excellence and make positive contributions to the nation.
Context: Following concerns about a potential decline in voter turnout during the first phase of the Lok Sabha election due to heatwave conditions, the Election Commission (EC) has established a task force.Â
- Comprising officials from the EC, the India Meteorological Department (IMD), the National Disaster Management Authority (NDMA), and the Union Health Ministry, this task force aims to assess the impact of prevailing weather conditions on health and humidity preceding each phase of polling.
Voter Turnout Concerns
- The voter turnout for the first phase of polling on April 19 was reported at 62.34%, with final figures yet to be released by the EC.
- Reports suggest variations in turnout figures, with some sources indicating slightly higher percentages.
- The EC emphasizes the validity of data available on the Voter Turnout App but has not provided an official statement on the turnout percentages.
Factors Influencing Turnout
- Heatwave conditions in various regions are considered a significant factor contributing to the observed dip in voting percentage.
- The EC conducted a meeting with the IMD and representatives of the Union Home Ministry to assess the developing weather situation and discuss measures to address potential risks associated with hot weather during elections.
Mitigation Measures
- The task force will monitor weather conditions and assess potential risks to voter health and turnout before each phase of polling.
- The IMD has provided assurances regarding the absence of major concerns related to heatwaves for the upcoming second phase of elections on April 26.
3. Two women Navy officers return after a historic transoceanic expedition
Context: The Indian Naval Sailing Vessel INSV Tarini recently completed a historic transoceanic expedition, marking a significant achievement for the Indian Navy and the nation as a whole. Led by two women officers, Lieutenant Commander Dilna K. and Lieutenant Commander Roopa A., this expedition represents the first such feat accomplished by Indian women sailors.
Historic Expedition
- The expedition, undertaken in double-handed mode, commenced from Goa on February 28, with renowned circumnavigator Commander Abhilash Tomy (Retd) as their mentor.
- After 22 days of navigating the Indian Ocean, INSV Tarini reached Port Louis, Mauritius, on March 21, marking a historic milestone.
- During their stay in Mauritius, the officers engaged in various events and training sorties with personnel from the Mauritius Coast Guard, strengthening bilateral ties between the two maritime nations.
Challenges and Resilience
- The return journey posed continuous challenges, including heavy winds, adverse sea states, and rough seas, yet the officers demonstrated exceptional seamanship and resilience.
- Their achievements highlight the Indian Navy’s commitment to promoting gender equality and empowering women in the maritime domain.
Future Expeditions
- Lieutenant Commander Dilna and Lieutenant Commander Roopa are now preparing for their next monumental voyage, a circumnavigation of the globe, known as the Sagar Parikrama-IV expedition, scheduled to commence in September this year.
Significance
- The successful completion of the transoceanic expedition by two women Navy officers signifies a significant milestone in India’s maritime history.
- It reflects the Indian Navy’s commitment to gender equality and the empowerment of women in traditionally male-dominated fields.
- The expedition strengthens bilateral ties with Mauritius and enhances India’s maritime capabilities and reputation on the global stage.
G. Tidbits
Nothing here for today!!!
H. UPSC Prelims Practice Questions
Q1. Consider the following statements with respect to INSV Tarini:
- INSV Tarini is a sailing vessel built in India.
- It is the first sailboat of the Indian Navy.
Which of these statements is/are correct?
- Only 1
- Only 2
- Both 1 and 2
- Neither 1 nor 2
CHECK ANSWERS:-
Answer: a
Explanation: It is the second sailboat of the Indian Navy after INSV Mhedi.
Q2. Consider the following statements with respect to National Disaster Management Authority (NDMA):
- It is an agency of the Ministry of Home Affairs.
- It is a statutory body.
- It is headed by the Home Minister.Â
How many of these statements is/are incorrect?
- Only one
- Only two
- All three
- None
CHECK ANSWERS:-
Answer: a
Explanation: Statement 3 is incorrect. It is headed by the Prime Minister.Â
Q3. Consider the following statements:
- Padma Vibhushan is India’s second-highest civilian award.
- All the Padma awards are conferred by the President of India.
- Padma Shri is India’s highest civilian award. Â
How many of these statements is/are correct?
- Only one
- Only two
- All three
- None
CHECK ANSWERS:-
Answer: b
Explanation: Statement 3 is incorrect. Bharat Ratna is the highest civilian award in India. Padma Shri is the fourth-highest civilian award.Â
Q4. Consider the following statements with respect to Escherichia coli:
- Escherichia coli is a gram-negative bacteria.
- It is found in the intestines of humans and animals.
Which of these statements is/are correct?
- Only 1
- Only 2
- Both 1 and 2
- Neither 1 nor 2
CHECK ANSWERS:-
Answer: c
Explanation: Both the statements are correct.Â
Q5. Consider the following statements with respect to star campaigners:
- Political parties can appoint a certain number of star campaigners, with a maximum of 40 for recognized political parties and up to 20 for registered unrecognised parties.
- Their names must be communicated to the Election Commission and Chief Electoral Officer within 7 days of election notification.
Which of these statements is/are correct?
- Only 1
- Only 2
- Both 1 and 2
- Neither 1 nor 2
CHECK ANSWERS:-
Answer: c
Explanation: Both the statements are correct.
I. UPSC Mains Practice Questions
- Elaborate upon the need for a new rights-based approach in dealing with climate change in India, with special reference to vulnerable communities. (20 Marks, 250 Words) (General Studies – II, Social Justice)​
- Discuss the challenges associated with drug discovery to combat antimicrobial resistance (AMR) and the role of collaborative efforts in addressing this global health threat. (20 Marks, 250 Words) (General Studies – III, Science and Technology)​
Read previous CNA articles here.
Comments