CNA 28 Feb 2023:- Download PDF Here
TABLE OF CONTENTS
A. GS 1 Related B. GS 2 Related C. GS 3 Related SCIENCE AND TECHNOLOGY 1. βOrgan on a chipβ: a tech which mimics disease systems in laboratory conditions D. GS 4 Related E. Editorials ENVIRONMENT AND ECOLOGY 1. Unpacking the new set of e-waste rules INTERNATIONAL RELATIONS 1. The New START treaty on pause F. Prelims Facts 1. National Science Day 2. Section 126 of Representation of the People Act of 1951 3. Hindustan 228-201 LW aircraft G. Tidbits 1. 1,300-year-old Buddhist stupa found in Odishaβs Jajpur 2. U.K., EU start βnew chapterβ over N. Ireland trade pact H. UPSC Prelims Practice Questions I. UPSC Mains Practice Questions
A. GS 1 Related
Nothing here for today!!!
B. GS 2 Related
Nothing here for today!!!
C. GS 3 Related
Category: SCIENCE AND TECHNOLOGY
1. βOrgan on a chipβ: a tech which mimics disease systems in laboratory conditions
Syllabus: Science and Technology- developments and their applications and effects in everyday life.
Prelims: Organ on a chip technologyΒ
Mains: Key issues associated with the existing procedure for introducing a new drug and the significance and advantages of using Organ on a chip technology
Context
The passage of the Food and Drug Administration Modernization Act 2.0 by the US government in December 2022 is expected to provide momentum to the R&D of βorgan chipsβ.
Organ chips or Organ on a chip model
- Organ chips are small devices with human cells that are used to mimic the environment in human organs such as blood flow and breathing movements, that can act as synthetic environments to test new drugs.
- Such chips are translucent which helps provide a window for researchers to look into the inner workings of the organ being studied.
- Donald Ingber, a professor of bioengineering and director of the Wyss Institute at Harvard University along with his colleagues developed the first human organ-on-a-chip model in 2010.Β
- This first organ-on-a-chip model was a βlung on a chipβ that resembled the biochemical aspects of the lung and its breathing mechanism.
- Later in 2014, members of the Wyss Institute started a startup named βEmulate Inc.β to commercialise the organ-on-a-chip technology.Β
- This group of researchers at Emulate Inc have created various such different chips which include that of the epithelial barrier, bone marrow, kidney, gut, vagina and liver.
Benefits and significance of Organ chipsΒ Β
- The most significant advantage of using Organ on a chip technology is that it can help predict how specific organs respond to the exposure of a potential chemical hazard found in foods, cosmetics and/or dietary supplements with better precision than other methods currently in use such as cell-culture or animal-based tests.
- Further, the Organ on a chip model is seen to be an alternative for clinical trials of drugs on animals which are criticised widely as an unethical and scientifically bogus practice.
- Organ chips can thus help prevent the death of thousands of laboratory animals.
- The technology can be used to identify, develop, and test novel drugs to treat a host of different diseases in a reliable manner and predict treatment outcomes better than conventional systems.
- Example: the liver chips developed by Emulate Inc could predict the ability of drugs to cause liver injury with 87% sensitivity and 100% specificity.Β
- Further, the liver chips were used to assess the toxic effects of 27 drugs known to be either safe or unsafe for human livers.
- The organ chips developed from isolating cells from a patient to develop biomimetic tissues that mimic a specific disease can be used to extend personalised therapies for individual patients.
Existing procedure followed for introducing a new drug
Key issues:
|
Organ chips in India
- A few of the research groups in India have also involved themselves in developing new organ-on-chip models.
- Researchers and experts at the Institute of Chemical Technology, Mumbai along with a team of chemical engineers at IIT Bombay have developed a skin-on-chip model.
- This model is being tested for studying skin irritation and toxicity.Β
- This group of experts has also developed a retina-on-chip model.
- Researchers in India are also developing a placenta-on-chip model.
- Apart from organs, researchers are also trying to mimic different diseases using organ chips.Β
- A team of experts at the Savitribai Phule Pune University (SPPU), have developed an infection-on-a-chip model to recreate a human skin wound infection state.Β
- The objective is to mimic an infection that doesnβt heal despite repeated antibiotic treatment.
Path ahead
- A few of these organs-on-chips models developed by Indian scientists are ready for use as drug test beds in laboratories. However, the implementation of these models must be given a push so that the industry adopts these technologies quickly.
- There is a need for forging collaborations with academia in order to extend training programmes to popularise the technology and get government support.
- Researchers in the West are looking to develop larger and more complex human-on-chip models such as micro-brain bioreactors and assemblies of different organ chips containing nutrients for the cells flowing across them, mimicking the flow of blood and nutrients across different organs in the body.Β
- Such models can help evaluate the efficacy of a drug against a disease in the presence of multiple organ systems instead of isolated systems.
Nut graf: In the wake of ethical concerns surrounding the use of animals in the clinical testing of drugs, various alternative methods are gaining attention. In this context, the development of organ-on-a-chip technology marks a significant shift in the clinical trial landscape as it is not just a reliable approach for drug testing but also a humane approach as it negates animal suffering.
D. GS 4 Related
Nothing here for today!!!
E. Editorials
Category: ENVIRONMENT AND ECOLOGY
1. Unpacking the new set of e-waste rules
Syllabus: GS-3, Environmental pollution and degradation.
Mains: New e-waste rule and associated concerns.
Context: New e-waste rules will come into force on 1st April 2023.
Details:
- In the era of rapid urbanization, digitalisation, and population growth, managing e-waste has become a big challenge.
- A set of E-waste rules was first notified in 2011 (came into effect in 2012).Β
- An important component of the rules was Extended Producer Responsibility (EPR).
- EPR implies that βproducersβ are responsible for the safe disposal of electronic and electric products once the consumer discards them.
- E-waste rules 2016 (amended in 2018) were comprehensive rules and introduced features likeΒ βauthorizationβ and βproduct stewardshipβ. It also proposed the provisions of βProducer Responsibility Organisations (PRO)β.
- The Ministry of Environment, Forests, and Climate Change (MoEFCC) notified a new set of e-waste rules in November 2022 (it will come into force on 1st April 2023).
For more information on e-waste, read here: Electronic Waste β E-waste Management Rules 2016
Salient features of the new e-waste rules:
- It includes the provision of an EPR framework with the mandatory requirement of βRegistration of Stakeholdersβ (manufacturer, producer, refurbisher, and recycler).
- A βdigitalized systems approachβ is also proposed in the new rules (2022) which will address the challenges of the weak monitoring systems, lack of transparency, inadequate compliance, and channelizing processing to the informal sector (which is a violation of the law).
- A common digital portal will also reduce instances of βpaper tradingβ or βfalse trailsβ. It means the practice of falsely revealing 100% collection on paper while collecting and/or weighing βscrapβ to meet targets.
- It also briefly touches on the two aspects namely βcomponent recoveryβ and βresidual disposalβ.
- Component recovery refers to adequate and efficient recoveries of rare earth metals so as to reduce dependence on virgin resources.
- Residual disposal means the safe disposal of the βresidualβ material during the e-waste recycling process.
Associated concerns:
- It is argued that the proposed rules do not clearly state the requirement for ensuring the βrecovery tangentβ.Β
- Moreover, the new rules eliminate the PRO and dismantlers and give the entire responsibility of recycling to authorized recyclers.
- It should be noted that PROs acted as an intermediary between producers and formal recyclers and arranged for βcertified and authorizedβ recycling.
- They also ensured βdouble verificationβ in terms of the quantity and quality of recycling.
- The new rules neglect the role of the informal sector despite the fact that 95% of e-waste is channelized by them.
- Notably, all the stages (collection, segregation, and clustered accumulation of e-waste) do not involve any hazardous practices.
- It is probably the last stage, where e-waste is handed over to the informal dismantlers/recyclers, which poses a major concern in e-waste management.
- Many producers have not established collection centres. Similarly, formal companies fail to provide facilities for doorstep collection to consumers.
- Moreover, consumers lack awareness of the existence of e-waste collection services.
Way Ahead:
- The activities of the recyclers should be recorded and the authorities should periodically monitor the quantity of e-waste undergoing the recycling process.
- Integration of informal aggregators in the collection mechanism – This will provide a safe and structured system and will provide financial and legal security to the informal sector. For example, the initiative of βKaro Sambhavβ in Delhi.
- For the efficient implementation of the law, stakeholders should have the appropriate information with a clear intent of safely disposing of the e-waste.
- It is also important to:
- Raise consumer awareness
- Strengthen reverse logistics
- Build the capacity of stakeholders
- Improve existing infrastructure
- Enhance product design
- Rationalize input control (particularly by defining βrare earth elementsβ as βcritical raw materialsβ)
- Adopt green procurement practices.Β
- Ensure a robust collection and recycling system
Also read: Sansad TV Perspective: Tackling E waste
Nut Graf: New e-waste management rules have been notified by the government. However, it has multiple challenges like the reduced role of the informal sector, which needs to be addressed on an urgent basis as the informal sector is the βfaceβ of e-waste disposal in India.
Category: INTERNATIONAL RELATIONS
1. The New START treaty on pause
Syllabus: GS-2, Effect of policies and politics of the developed world.
Mains: New START treaty.
Prelims: New START treaty.
Context: The Russian President announced the suspension of its participation in the New START treaty (February 2023).
Details:
- On the eve of the first anniversary of Russiaβs βspecial military operationβ in Ukraine (23rd February 2023), Russian President Vladimir Putin said that Russia was unilaterally suspending the last remaining nuclear arms control treaty (New START) with the U.S.
- The U.S. Secretary of State, Antony Blinken, responded by terming the move as βdeeply unfortunate and irresponsibleβ.
- The START treaty was signed in 1982 by Ronald Reagan and Mikhail Gorbachev, the then leaders of the U.S. and the erstwhile Soviet Union respectively.
For more details, read here: Strategic Arms Reduction Treaty [New START Treaty]
Background Details:
- The U.S. and Russia engaged in multiple bilateral talks to reduce and keep checks on each otherβs nuclear arsenals. For instance,
- The Strategic Arms Limitation Talks (SALT) was the first formal dialogue in 1969.
- The Anti-Ballistic Missile defence systems Treaty was signed in 1972. It provided for the shooting down of incoming missiles. It was unilaterally pulled out of the pact by the U.S. in 2002.
- In 1991, the Strategic Arms Reduction Treaty (START I) was signed (expired in 2009).
- The Strategic Offensive Reductions Treaty (SORT or Moscow Treaty) was signed in 2002. However, it was replaced by the New START treaty in 2010.
- The New START treaty was the last remaining nuclear weapons control agreement between Moscow and Washington that together hold 90% of the worldβs nuclear arsenal.
Details about the New START treaty:
- It was signed by former U.S. President Barack Obama and Russian President Dmitry Medvedev. It came into force in February 2011.
- In 2021, it was extended for five years.
- According to the Treaty, America and Russia cannot deploy more than 1,550 strategic nuclear warheads and more than 700 long-range missiles and bombers.Β
- It further limits the countries to 800 deployed and non-deployed launchers and delivery vehicles.Β
- Moreover, it allows both countries to carry out up to 18 short-notice (32 hours) on-site inspections of strategic nuclear weapons sites annually to check that the other country had not violated the limits set in the treaty.
- Russia and the U.S. should also exchange data on ballistic missiles, bombers, test sites, nuclear bases, etc twice a year.
- It also mandates the two countries to send notifications within five days of new changes or updates in their stockpile. For example, moving missiles to a new base or deploying a new warhead to the system.
- The agreement gave both countries seven years to reduce their stockpiles. Consequently, in 2018 both nations met the arms limits prescribed by the pact.
- It should be noted that the inspections were put on hold in March 2020 (due to COVID-19).
Russiaβs stand:
- Russian President Vladimir Putin said that while the U.S. had pushed for the resumption of inspections of Russian nuclear facilities, NATO allies were helping Ukraine to launch drone attacks on Russian air bases hosting nuclear-capable strategic bombers.
- Russia has also pointed out that the nuclear weapons of Britain and France were part of NATOβs nuclear capability but werenβt included in the U.S.-Russian pact.
- The U.S. is also accused of rejecting Russian requests for visits to specific U.S. facilities.
Consequences of the move:
- The analysts suggest that the move would not immediately trigger an arms race between the two powers, as Russia has not withdrawn from the treaty and only βsuspendedβ it.
- Moreover, the Russian administration has clearly stated that it does not plan to breach the limits on warheads prescribed in New START.Β
- Similarly, in another statement by the Russian Foreign Minister, Russia would continue to notify the U.S. of planned test launches of inter-continental ballistic missiles (ICBMs).
- It is also highlighted that the move is a political message indicating that Russia no longer thinks that nuclear arms control is a separate issue from bilateral relations (Russia-Ukraine conflict).
- Observers are of the view that Russiaβs move will disturb the fragile calculus of nuclear arms controls between the two largest nuclear powers.
- It will also give an opportunity to other nuclear-armed countries, particularly China and others (Pakistan, Iran, Israel, and India) to increase their arsenals.
- It also has the potential to hamper arms control cooperation between the U.S. and China.
Also read: Nuclear Arms Control – Non-Proliferation Treaty & India and US Nuclear Deal
Nut Graf: Russiaβs move to suspend the New START treaty has raised concerns for international peace. It would give the opportunity to other nuclear-armed countries to increase their arsenals.
F. Prelims Facts
Syllabus: GS-3; Science and Technology
Prelims: National Science Day and about Sir C.V. Raman
National Science Day
- India celebrates National Science Day every year on February 28th.
- In 1986, the Union Government, under then Prime Minister Rajiv Gandhi, designated February 28 as National Science Day.
- National Science Day is celebrated every year to commemorate the discovery of the βRaman Effectβ by Sir C.V. Raman.
- Physicist Sir CV Raman won the Nobel Prize in 1930 for the discovery of the Raman Effect.
- The theme for National Science Day 2023 in light of Indiaβs G20 presidency is βGlobal Science for Global Wellbeingβ.
Read more about – National Science Day
About Sir C.V. Raman
- Sir C.V. Raman was born on 7th November 1888 in Tiruchirapalli in modern Tamil Nadu.
- From an early age, Raman was exposed to science. He was a brilliant student and joined the Presidency College at Chennai in 1902 aged just 13 for his graduation. He passed out in 1904 with a Gold Medal in Physics. He completed his post-graduation from the University of Madras in 1907 with distinction.
- He continued to do research at the Indian Association for Cultivation of Sciences in Calcutta (IACS) and also published papers in leading international journals such as βNatureβ and βPhysics Reviewβ.
- It was at IACS that Raman along with his collaborators discovered what is now called the βRaman Effectβ.
- This discovery on the scattering of light was made on February 28, 1928.Β
- This effect proved the quantum nature of light and had huge value at that time.Β
- The Raman Spectroscopy was based on this phenomenon.Β
- For this discovery, Raman was awarded the Nobel Prize in Physics in the year 1930. He became the first Indian, Asian and non-white person to win a Nobel Prize for the sciences.
- In 1933, he became the first Indian Director of the Indian Institute of Science (IISC) in Bangalore. He was the instituteβs director till 1937 and the Head of the Physics Department till 1948.
- In 1948, he founded the Raman Research Institute (RRI) in Bangalore for conducting experiments in Physics. He continued to do research at RRI till his death in 1970.
- Honours and awards:
- Knighthood β 1929
- Nobel Prize (Physics) β 1930
- Bharat Ratna β 1954
- Lenin Peace Prize β 1957
2. Section 126 of Representation of the People Act of 1951
Syllabus: GS-2; Polity; Powers, functions and responsibilities of various Constitutional Bodies – Election Commission
Prelims: Election Commission (EC) and Section 126 of the Representation of the People Act
Context
The Election Commission (EC) has asked social media platform Twitter to take down a video post on Meghalayaβs Deputy Chief Minister as its content was found to be in violation of the provisions of the Representation of the People Act of 1951.
Section 126 of the Representation of the People Act
- Section 126 of the Representation of the People Act (RP Act), 1951, inter-alia, prohibits election campaign activities through public meetings, processions, etc.
- Section 126 of the RP Act, 1951 deals with the prohibition of public meetings during a period of 48 hours ending with an hour fixed for the conclusion of the poll.
- According to Section 126 (1):
- Section 126(1)(a): No person shall hold, attend, or address any public meeting or procession in connection with an election.
- Section 126(1)(b): No person shall display to the public any election matter by means of cinematograph, television or other similar means.
- Section 126(1)(c): No person shall propagate any election matter to the public in any polling area during the period of 48 hours ending with the hour fixed for the conclusion of the poll for any election in that polling area.
- Section 126 (2) of the RP Act provides the provisions for punishment with imprisonment up to two years or a fine, or with both for individuals who violate the provisions of Section 126 (1) of the RP Act.
Read more about – Representation of People Act, 1951
3. Hindustan 228-201 LW aircraft
Syllabus: GS-3; Defence and Security
Prelims: About Hindustan 228-201 LW aircraft
Context
The Directorate General of Civil Aviation (DGCA) has approved a new variant of the Hindustan 228-201 LW aircraft.
Hindustan 228-201 LW aircraft
- Hindustan 228-201 LW aircraft is developed by the defence PSU, Hindustan Aeronautics Limited (HAL).
- The Hindustan 228-201 LW is a modified version of the German Dornier-228 aircraft of the HAL.
- The Dornier-228 aircraft has been in use for short-range maritime patrol and surveillance by the Indian Navy and Coast Guard.Β
- In 2016, HAL decided to produce a civilian version of the aircraft with the launch of the Hindustan 228 variant.
- HAL has added advanced features to the Dornier 228 such as the FLIR system, satellite communication tools, ESM technology, speech encryption, etc.
- According to HAL, the Hindustan 228-201 LW version of the aircraft has a maximum take-off weight of 5,695 kg with 19 passengers and the aircraft would fall in the sub-5,700 kg aircraft category.
- This variant of the aircraft offers various operational benefits such as reduced pilot qualification requirements, enabled pilots with a commercial license to fly the aircraft, reduced operational cost and reduced training requirementsΒ
Know more about – Dornier Aircrafts
G. Tidbits
1. 1,300-year-old Buddhist stupa found in Odishaβs Jajpur
- The Archaeological Survey of India (ASI) has found a 1,300-year-old stupa in the middle of a mining site in Odishaβs Jajpur district from where Khondalite stones were excavated for the project around the Jagannath Temple in Puri.
- According to preliminary analysis, the stupa is 4.5 metres tall and may belong to the 7th or 8th century.
- This stupa was found at Parabhadi situated near Lalitagiri, which was a major Buddhist complex, having a large number of stupas and monasteries.Β
- Post the discovery of the Buddhist stupa from the mining site, the ASI intervened and asked the Odisha government to stop mining in the location.
- The ASI would now try to fully retrieve the structureβs archaeological heritage, restore it to its original form and undertake the protection of the site.
- Experts opine that the State government must conduct a heritage assessment of a site when it is located near any place of archaeological interest, before giving permission for mining as the destruction of smaller artefacts such as stupas cannot be restored if destroyed.
2. U.K., EU start βnew chapterβ over N. Ireland trade pact
- The British Prime Minister has negotiated a new deal with the European Union (EU) on post-Brexit trade rules for Northern Ireland.
- According to the British Prime Minister, the deal would pave the way for a new chapter in Londonβs relationship with the bloc.
- Northern Ireland, which is a British province, has an open border with Ireland, which is an EU member.Β
- The deal seeks to resolve tensions caused by the 2020 post-Brexit arrangements governing Northern Ireland and its open border with the Republic of Ireland.
- The issue has triggered the collapse of the regional government, and affected Northern Irelandβs peace process and ties between the UK and EU.
- The new deal is expected to ease physical checks on goods flowing from other parts of the UK to Northern Ireland.
H. UPSC Prelims Practice Questions
Q1. Which one of the following statements is/are true regarding the Legislative Councils?Β (Level β Difficult)
- It is a permanent house, unlike the Legislative Assembly.
- 1/12th of its total members are nominated by the Governor.
- To be a member of a stateβs Legislative Council, the person should be an elector or a resident of that state.
Options:
- 1 and 2
- 2 and 3
- 1 and 3
- 1, 2 and 3
CHECK ANSWERS:-
Answer: c
Explanation:
- Statement 1 is correct, Unlike the Legislative Assembly, the Legislative Council is not subject to dissolution and hence is a permanent body unless abolished by the Legislative Assembly and Parliament by due procedure.Β
- Statement 2 is not correct, One-sixth of the members of the Legislative Council are nominated by the Governor from persons having knowledge or practical experience in matters like science, literature, cooperative movement, art and social service.
- Statement 3 is correct, A person shall not be qualified to be chosen to fill a seat in the Legislative Council of a State to be filled by election unless he is an elector for any Assembly constituency in that State.
Q2. How many of the following statements is/are true regarding Sickle Cell Disease? (Level β Moderate)
- The Government plans to bring a mission to eliminate the disease in India by 2047.
- It is covered under the Pradhan Mantri Jan Aarogya Yojana.
- It is a hereditary genetic disease.
Options:
- Only 1 statement
- Only 2 statements
- All 3 statements
- None of the statements
CHECK ANSWERS:-
Answer: c
Explanation:
- Statement 1 is correct, The Union Finance Minister while presenting the Union Budget 2023-24 has announced that the government will work in βmission modeβ to eliminate sickle cell anaemia by 2047.
- Statement 2 is correct, Sickle Cell Disease is covered under the Pradhan Mantri Jan Aarogya Yojana and provides full treatment for sickle cell disease, free of cost.
- Statement 3 is correct, Sickle Cell Disease is an inherited genetic blood disorder or red blood cell (RBCc) disorder.
Q3. Which of these statements are true about the Agnipath Scheme?Β (Level β Easy)
- It will recruit youth between the ages of 18-25 years every year.
- 75% of the recruited youth will serve only for 4 years.
Options:
- 1 only
- 2 only
- Both 1 and 2
- Neither 1 nor 2
CHECK ANSWERS:-
Answer: b
Explanation:
- Statement 1 is not correct, The Agnipath scheme was launched by the Indian government to hire individuals for the Army, Navy, and Airforce.
- The minimum age for applying under this yojana is 17.5 years & maximum age is 21 years.
- Statement 2 is correct, According to the Agnipath scheme, after the completion of four years on the job, 75% of the soldiers will be discharged from their services and only 25% will be allowed to continue for another 15 years under permanent commission.
Q4. Which of the following is/are true? (Level β Moderate)
- Inelastic products are those whose demand or supply changes rapidly with their price.
- The supply of perishable goods is inelastic.
- The demand for food commodities is inelastic.
Options:
- 1 only
- 2 and 3 only
- 1 and 2 only
- 1, 2 and 3
CHECK ANSWERS:-
Answer: b
Explanation:
- Statement 1 is not correct, Inelastic products are those whose demand does not change relative to changes in prices.
- i.e. the demand for such goods or services remains unchanged even when the price changes.
- Statement 2 is correct, Supply of perishable goods is inelastic as the supply of such goods cannot be increased or decreased easily.
- Statement 3 is correct, The demand for food is relatively inelastic as it is considered a basic necessity.
Q5. Which one of the following statements correctly describes the meaning of legal tender money? (Level β Moderate) [PYQ 2018]
- The money which is tendered in courts of law to defray the fee of legal cases
- The money which a creditor is under compulsion to accept in settlement of his claims
- The bank money in the form of cheques, drafts, bills of exchange, etc.
- The metallic money in circulation in a country
CHECK ANSWERS:-
Answer: b
Explanation:
- Legal tender means banknotes and coins which are offered in payment of debts and which must be accepted.
- Legal tenders are those currencies which cannot be refused by any citizen of the country for the settlement of any kind of transaction.
I. UPSC Mains Practice Questions
- Critically examine the e-waste (Management) Rules, 2022. (15 marks, 250 words) [GS-3, Environment & Ecology]
- Will Russia’s suspension of the New START Treaty lead to a new global arms race? Evaluate. (15 marks, 250 words) [GS-2, International Relations]
Read the previous CNA here.
CNA 28 Feb 2023:- Download PDF Here
Comments