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Question

Is anisole undergoes Friedel crafts reaction?


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Solution

  1. In the presence of anhydrous aluminium chloride(AlCl3) as a catalyst, anisole reacts with acetyl chloride(CH3COCI) to form 2-methoxyacetophenone and 4-methoxyacetophenone.
  2. The reaction is the acylation reaction by Friedel Craft (an electrophilic aromatic substitution reaction) and given in detail diagram below:

  1. The detailed mechanism of the reaction is given below:

  1. The Methoxy group is the ortho-para group of directors.

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