Question

Chronic autoimmune disorder affecting neuromuscular junction leading to fatigue, weakening, and paralysis of skeletal muscle is called as:

• A. Arthritis
• B. Muscular dystrophy
• C. Gout
• D. Myasthenia gravis

Answer 1

The correct option is D

Myasthenia gravis

The correct option is D.

The explanation for the correct option:

1. In myasthenia gravis, the normal communication between nerves and muscles got disrupted.
2. In this autoimmune disease, the immune system forms antibodies that block or destroy the muscle receptor sites of the neurotransmitter acetylcholine in the neuromuscular junctions.
3. As fewer receptor sites are available muscle receives fewer nerve signals, so the result is muscle weakness, fatigue, and paralysis of skeletal muscle.

The explanation for the incorrect options:

Option A:

1. Arthritis is characterized by inflammation of one or more joints, pain, stiffness, and swelling that are more prominent with aging.
2. Osteoarthritis is not an autoimmune disease.
3. Rheumatoid arthritis is separate from osteoarthritis and is an autoimmune condition.

Option B:

1. Muscular dystrophy is genetic, it is a group of diseases described by loss of muscle and progressive weakening of muscles.
2. In this disease, mutations in gene impede the production of proteins required for healthy muscle.

Option C:

1. Gout is a common type of arthritis in which joint pain, redness, tenderness, swelling, and stiffness are common symptoms.

Final answer: Chronic autoimmune disorder affecting neuromuscular junction leading to fatigue, weakening, and paralysis of skeletal muscle is called as myasthenia gravis.