Question

How do I calculate allele frequency?

Answer 1

Calculation of allele frequency: -

1. The incidence of a gene variant in a population is represented by allele frequency.
2. Alleles are different versions of a gene that share the same genetic locus on a chromosome.
3. The number of times the allele of interest is observed in a population is divided by the total number of copies of all the alleles at that genetic locus in the population to get an allele frequency.
4. A decimal, a percentage, or a fraction can be used to express allele frequencies.
5. Allele frequencies in a population reflect genetic variety. Changes in allele frequencies over time can reflect genetic drift or the introduction of new mutations into the population.
6. The Hardy-Weinberg (HW) Equation is used by scientists to determine the frequency of alleles in a population. The Hardy-Weinberg equation looks like this:

1 = p²+2pq+q²

Where

The allele frequency of distinct alleles is represented by p and q.
The word p² refers to the homozygous dominant genotype's frequency.
The alternative term, q², refers to the homozygous recessive genotype's frequency.