Question

How do you calculate 2pq?

Answer 1

Hardy Weinberg Principle:

1. The Hardy Weinberg equation refers to the calculation of the genetic variation of a population at an equilibrium state. The equation is expressed as: p² + 2pq + q² = 1
2. Let, a height determining gene is expressed by two alleles ‘L’ and ‘l’, where p is the frequency of “L” allele and q is the frequency of ‘l'' allele.
3. p² represents homozygous genotype “LL”
4. q² represents homozygous genotype ‘ll’
5. p q represents heterozygous genotype Ll.
6. According to the equation, p+ q=1.
7. If the allele frequencies are known then the gene frequencies can be calculated from the equation if there is no mutation, gene flow, random mating, and selection occurred. It is just a theoretical approach to predicting gene frequency.

According to Hardy Weinberg equilibrium:

p²+2pq+q²=1

In the equation to calculate the 2Pq,

p² + 2pq + q² = 1

=> 2pq = 1– p² – q²

∴ 2pq = 1– p² – q².