Question

Inhibition of succinic dehydrogenase by malonate is an example of

• A. Competitive inhibition
• B. Non-competitive inhibition
• C. Negative feedback
• D. Allosteric inhibition

Answer 1

The correct option is A

Competitive inhibition

The correct option is A

Explanation of correct option:

1. In competitive inhibition, a competitive inhibitor instead of a substrate binds with the active site, inhibiting the reaction.
2. Competitive inhibition is demonstrated by malonate's inhibition of succinic dehydrogenase.
3. Competitive inhibitors have a structure that is similar to that of the substrate and bind to the active site, inhibiting enzyme activity.

Explanation of incorrect options:

Option B

1. When an inhibitor binds to the enzyme in a location other than the active site, it is known as non-competitive inhibition.
2. The inhibitor is thought to bind to the enzyme in such a way that it physically blocks the normal active site in some cases of noncompetitive inhibition.

Option C

1. Negative feedback inhibition occurs when a biological reaction's product prevents the reaction from continuing.
2. For example, feedback inhibition occurs when the cell has produced enough product and needs to stop producing additional products.

Option D

1. The slowing down of enzyme-catalyzed chemical reactions in cells is known as allosteric inhibition.
2. Allosteric inhibition can aid in the regulation of these metabolic processes, which are necessary for the proper functioning and maintenance of our bodies' balance.

Final answer: Inhibition of succinic dehydrogenase by malonate is an example of competitive inhibition.